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Please see the full solicitation for complete information about the funding opportunity. Below is a summary assembled by the Research & Innovation Office (RIO).

Program Summary

The program’s purpose is to build new research capacity and develop a sustainable research program by supporting the purchase of a single commercially available biomedical research instrument currently unavailable in the institution. Instruments funded through this program must be shared among the users to create new research opportunities, enable reproducible data generation, encourage collaborative research and training, and strengthen long-term research capabilities.Ìý

For research-intensive institutions, emphasis is placed on acquiring new or emerging technologies that enable innovative and novel research.Ìý

Eligible instruments include, but are not limited to, mass spectrometers, cell sorters, bioimagers, DNA and protein sequencers, light microscopes, 3D printers, and high-performance computers. Applications for general purpose computer systems (computer clusters and data storage systems) will only be considered if the system is solely dedicated to biomedical research.

Foreign-made instruments are allowed. However, the reasons for choosing foreign-made instruments over domestically manufactured instruments will be justified. NIH urges that every effort should be made to give preference to domestically manufactured instruments to the maximum extent possible. Additionally, requesting funds towards purchasing an instrument under a lease agreement is strongly discouraged.

The following types of applications are not responsive to this NOFO and will not be reviewed:

• Instruments or integrated systems that are not commercially available and do not have a manufacturer's warranty.
• More than one stand-alone workstation for data processing, multiple software licenses, and duplicate software items.
• Software, unless it is integrated in the operation of the instrument and/or necessary for generation of high-quality experimental data from the instrument.
• Research equipment to furnish a research facility (such as autoclaves, hoods, equipment to upgrade research facilities) or general-purpose equipment (such as standard machine shop equipment), equipment for routine sustaining infrastructure (such as standard computer networks or general-purpose data storage systems).
• Purely instructional equipment.
• Disposable devices, office furniture, and supplies.
• Alteration or renovation of space to house the instruments.

Applications proposing such requests will be considered non-responsive and will not be reviewed or considered for funding.

Deadlines

• Â鶹Ãâ·Ñ°æÏÂÔØInternal Deadline: 11:59pm MT August 3, 2026
• Sponsor Application Deadline: 5:00pm MT September 25, 2026

Internal Application Requirements (all in PDF format)

• Project Summary (3 pages maximum): Describe the requested instrument’s model, features and how it will catalyze new research directions and long-term research capacity. Identify anticipated major users, their NIH-funded projects, and estimated instrument utilization. Describe technical expertise, instrument management, user training, and plans for shared access. Describehousing, operation, maintenance, and long-term sustainability of the instrument. List the names and titles of the members of the local Advisory Committee.Ìý
• PI Curriculum Vitae / Biosketch
• Budget Overview (1 page maximum): A basic budget outlining project costs is sufficient; detailed OCG budgets are not required.

To access the online application, visit: ÌýÌýÌýÌýÌýÌýÌýÌýÌý

Eligibility

A minimum of two NIH-funded users must be identified, with at least one of the NIH-funded users must be from the applicant institution. NIH-funded users from other institutions are highly encouraged. Each of the NIH funded users must be a PD/PI on a distinct active NIH award (i.e., a grant or a cooperative agreement). An award given to multi-PDs/PIs is counted only once towards the fulfillment of this requirement. Users with funding from sources such as other Federal agencies, private foundations, or academic institutions are eligible to use the instrument. To justify the requested instrument, the projects supported by NIH research awards should together have a preponderant use of the instrument. While training, curricular instructions, or other non-biomedical research activities may be supported by the instrument, for-profit activities or billable clinical care are not allowed to use the instrument.Ìý

Note: The SIS S10 Program is intended to promote innovation and foster sustainable research programs at applicant institutions. Institutions that focus primarily on development rather than research or short-term awards, such as an SBIR/STTR grant, do not directly align with the goal of developing a sustainable research program and may be incompatible or less competitive for this program.Ìý

Limited Submission Guidelines

Applicant organizations may submit only one application, provided that the type of instrument does not currently exist in the applicant organization.

Award Information

• Minimum award is $50,000. Maximum award is $400,000.
• Award Duration: One yearÌý

Review Criteria

Please reference the NIH application for full details. The internal evaluation will follow NIH’s guidance.Ìý